Brain development during the lifespan of cynomolgus monkeys
Zhiqiang Tan,
Binbin Nie,
Huanhua Wu,
Bang Li,
Jingjie Shang,
Tianhao Zhang,
Zeyu Xiao,
Chenchen Dong,
Chunyuan Zeng,
Biao Wu,
Lu Hou,
Bin Guo,
Yong Cheng,
Jian Gong,
Weijian Ye,
Lin Xu,
Yuefeng Li,
Xiaojiang Li,
Steven H. Liang,
Baoci Shan,
Hao Xu,
Lu Wang
Affiliations
Zhiqiang Tan
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Binbin Nie
Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Huanhua Wu
The Affiliated Shunde Hospital of Jinan University, Foshan 528305, China
Bang Li
College of A&F Engineering and Planning, Tongren University, Tongren 554300, Guizhou, China; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510630, China
Jingjie Shang
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Tianhao Zhang
Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Zeyu Xiao
The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China
Chenchen Dong
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Chunyuan Zeng
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Biao Wu
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Lu Hou
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Bin Guo
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Yong Cheng
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Jian Gong
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Weijian Ye
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Lin Xu
Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650223, China
Yuefeng Li
Guangdong Landau Biotechnology Co. Ltd., Guangzhou 510555, China
Xiaojiang Li
Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510630, China
Steven H. Liang
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States
Baoci Shan
Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authors.
Hao Xu
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Corresponding authors.
Lu Wang
Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510632, China; Corresponding authors.
The cynomolgus monkey has emerged as a predominant nonhuman primate model in neuroscience research. A comprehensive grasp of the growth and development patterns in the cynomolgus monkey brain is crucial for the judicious utilization of this species in neuroscience investigations. This project involved the collection of brain [18F]FDG PET-MRI data from 228 healthy cynomolgus monkeys spanning the age range of 0.5–29.5 years to construct an age-specific multimodal image brain template toolset tailored to cynomolgus monkeys. Their brain volume and glucose metabolism were quantitatively analyzed by utilizing an individualized spatial segmentation algorithm. Our findings encapsulated the growth and development trends, sex differences, and asymmetrical variations in brain volume and glucose metabolism in cynomolgus monkeys, and analyzed the correlation between the brain volume and glucose metabolism. This endeavor enhances our capacity to leverage the cynomolgus monkey model in neuroscience research by providing a valuable resource for researchers. The age-specific brain template toolset and associated data offer a robust foundation for future investigations, facilitating a nuanced understanding of brain development in this primate species and, consequently, informing and advancing neuroscience research employing cynomolgus monkeys.
