Consensus for Blood Purification Therapy Based on Pharmacokinetics in Acute Poisoning from Commonly Used Clinical Drugs

Abstract

The incidence of acute poisoning caused by commonly used clinical drugs has been increasing annually, yet specific antidotes are lacking for most drug poisonings. Blood purification plays a crucial role in the treatment of acute poisoning. However, there are currently no unified recommendations in China regarding its application in cases of acute poisoning from commonly used clinical drugs. This consensus centers on pharmacokinetics, summarizing and outlining the strategies for applying blood purification in the treatment of acute poisoning caused by these drugs. Its aim is to assist clinicians in improving their understanding of pharmacokinetic parameters and the corresponding blood purification methods, so that they can select the appropriate blood purification technique and develop suitable treatment plans based on the pharmacokinetic characteristics of the drug involved. Ultimately, this seeks to improve outcomes in treating patients with acute poisoning from commonly used clinical drugs.

Keywords

• poisoning|drug overdose|pharmacokinetics|continuous renal replacement therapy|acute poisoning|drug poisoning|blood purification