Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus

Abstract

Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. Case Report: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. Discussion: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.

Keywords

• Neurology
• Anti-glutamic acid decarboxylase
• GAD
• Limb myoclonus
• Anti-GAD
• Envephalopathy
• Steroids
• Patients