Nature Communications (Jan 2022)

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

  • Alicia S. Wilson,
  • Katrina L. Randall,
  • Jessica A. Pettitt,
  • Julia I. Ellyard,
  • Antje Blumenthal,
  • Anselm Enders,
  • Benjamin J. Quah,
  • Tobias Bopp,
  • Christopher R. Parish,
  • Anne Brüstle

DOI
https://doi.org/10.1038/s41467-022-28172-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Neutrophils are critical in the immune response to infective agents and have multiple effector strategies including the production of extracellular traps termed NETs. Here the authors show a link between NET production and Th17 differentiation which mechanistically occurs downstream of TLR2 signalling.