Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

Yuta Hikichi; Rachel Van Duyne; Phuong Pham; Jennifer L. Groebner; Ann Wiegand; John W. Mellors; Mary F. Kearney; Eric O. Freed

doi:10.1128/mBio.03134-20

mBio (Feb 2021)

Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

Yuta Hikichi,
Rachel Van Duyne,
Phuong Pham,
Jennifer L. Groebner,
Ann Wiegand,
John W. Mellors,
Mary F. Kearney,
Eric O. Freed

Affiliations

Yuta Hikichi: Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Rachel Van Duyne: Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Phuong Pham: Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Jennifer L. Groebner: Translational Research Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Ann Wiegand: Translational Research Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
John W. Mellors: Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mary F. Kearney: Translational Research Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Eric O. Freed: Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA

DOI: https://doi.org/10.1128/mBio.03134-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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