mBio
(Feb 2021)
Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
Yuta Hikichi,
Rachel Van Duyne,
Phuong Pham,
Jennifer L. Groebner,
Ann Wiegand,
John W. Mellors,
Mary F. Kearney,
Eric O. Freed
Affiliations
Yuta Hikichi
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Rachel Van Duyne
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Phuong Pham
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Jennifer L. Groebner
Translational Research Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Ann Wiegand
Translational Research Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
John W. Mellors
Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mary F. Kearney
Translational Research Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
Eric O. Freed
Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
DOI
https://doi.org/10.1128/mBio.03134-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.
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