Correlation of obstructive sleep apnea severity and lipid profile level

Abstract

Abstract Obstructive sleep apnea (OSA) is accompanied by different metabolic disorders and is linked with a heightened incidence of cardiovascular diseases and death. The information actively engaged in relating obstructive sleep apnea and dyslipidemia is quite uncertain. This research intended to determine the correlation between obstructive sleep apnea severeness and lipid profile abnormalities. Our study involved 120 cases diagnosed with OSA, who came to the chest department: at Benha University Hospital from September 2021 to December 2022. Included patients indicated for polysomnography because of suspected sleep-breathing disorders. Full history and clinical examination, and full polysomnography and blood samples for lipid profile, were done for all the cases. Results A total of 120 patients were involved in the study. Most cases were severe OSA (70%). The mean age in severe obstructive sleep apnea was 44.04 years with SD 9.49, Males were 92.9% in severe OSA, and the mean BMI in severe OSA was 36.63 with SD 7.79. LDL was positively correlated with AHI and DI (significantly); triglycerides were positively correlated with AHI, DI, and min oxygen saturation (significantly); and HDL was negatively correlated with AHI and DI significantly. Among lipid profile variables, LDL was the most predictor for AHI severity. Conclusion Lipid abnormalities are associated with OSA severity. Patients diagnosed with obstructive sleep apnea should be screened for lipid profile to correct any abnormality, hoping to prevent their harmful effects.

Keywords

• OSA
• LDL
• Triglycerides