BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Timo Reisländer; Emilia Puig Lombardi; Florian J. Groelly; Ana Miar; Manuela Porru; Serena Di Vito; Benjamin Wright; Helen Lockstone; Annamaria Biroccio; Adrian Harris; Arturo Londoño-Vallejo; Madalena Tarsounas

doi:10.1038/s41467-019-11048-5

Nature Communications (Jul 2019)

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Timo Reisländer,
Emilia Puig Lombardi,
Florian J. Groelly,
Ana Miar,
Manuela Porru,
Serena Di Vito,
Benjamin Wright,
Helen Lockstone,
Annamaria Biroccio,
Adrian Harris,
Arturo Londoño-Vallejo,
Madalena Tarsounas

Affiliations

Timo Reisländer: Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Emilia Puig Lombardi: Institut Curie, PSL Research University, CNRS, UMR3244
Florian J. Groelly: Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Ana Miar: Hypoxia and Angiogenesis Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford
Manuela Porru: Area of Translational Research, IRCCS Regina Elena National Cancer Institute
Serena Di Vito: Area of Translational Research, IRCCS Regina Elena National Cancer Institute
Benjamin Wright: Bioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of Oxford
Helen Lockstone: Bioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of Oxford
Annamaria Biroccio: Area of Translational Research, IRCCS Regina Elena National Cancer Institute
Adrian Harris: Hypoxia and Angiogenesis Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford
Arturo Londoño-Vallejo: Institut Curie, PSL Research University, CNRS, UMR3244
Madalena Tarsounas: Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-11048-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal