Frontiers in Cellular and Infection Microbiology (Oct 2021)
Donor-Derived Human Parvovirus B19 Infection in Kidney Transplantation
- Yedong Yu,
- Chunchun Wei,
- Chunchun Wei,
- Chunchun Wei,
- Chunchun Wei,
- Chunchun Wei,
- Junhao Lyu,
- Junhao Lyu,
- Junhao Lyu,
- Junhao Lyu,
- Junhao Lyu,
- Xiaoliang Wu,
- Rending Wang,
- Rending Wang,
- Rending Wang,
- Rending Wang,
- Rending Wang,
- Hongfeng Huang,
- Hongfeng Huang,
- Hongfeng Huang,
- Hongfeng Huang,
- Hongfeng Huang,
- Jianyong Wu,
- Jianyong Wu,
- Jianyong Wu,
- Jianyong Wu,
- Jianyong Wu,
- Jianghua Chen,
- Jianghua Chen,
- Jianghua Chen,
- Jianghua Chen,
- Jianghua Chen,
- Wenhan Peng,
- Wenhan Peng,
- Wenhan Peng,
- Wenhan Peng,
- Wenhan Peng
Affiliations
- Yedong Yu
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Chunchun Wei
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Chunchun Wei
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Chunchun Wei
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Chunchun Wei
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Chunchun Wei
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- Junhao Lyu
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Junhao Lyu
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Junhao Lyu
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Junhao Lyu
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Junhao Lyu
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- Xiaoliang Wu
- Department of Intensive Care Medicine, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Rending Wang
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Rending Wang
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Rending Wang
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Rending Wang
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Rending Wang
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- Hongfeng Huang
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Hongfeng Huang
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Hongfeng Huang
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Hongfeng Huang
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Hongfeng Huang
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- Jianyong Wu
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Jianyong Wu
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Jianyong Wu
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Jianyong Wu
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Jianyong Wu
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- Jianghua Chen
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Jianghua Chen
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Jianghua Chen
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Jianghua Chen
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Jianghua Chen
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- Wenhan Peng
- Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- Wenhan Peng
- Kidney Disease Immunology Laboratory, State Administration of Traditional Chinese Medicine of China, Hangzhou, China
- Wenhan Peng
- Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China
- Wenhan Peng
- Institute of Nephrology, Zhejiang University, Hangzhou, China
- Wenhan Peng
- Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China
- DOI
- https://doi.org/10.3389/fcimb.2021.753970
- Journal volume & issue
-
Vol. 11
Abstract
BackgroundDonor-derived human parvovirus B19 (B19V) infections are rarely reported. Thus, its incidence in kidney transplantation is still unknown due to lack of surveillance studies. Similarly, whether the donor needs to be routinely screened for B19V and whether the kidneys from those with B19V DNAemia could be accepted also remain unknown.MethodsThis retrospective study aims to evaluate the donor-derived B19V infections occurring in 823 living and 1,225 deceased donor kidney transplantations from January 2016 to December 2020. The serum viral load of living donors and their corresponding recipients was evaluated before and after transplantation. Meanwhile, for the deceased donor kidney transplantation, the serum viral load of recipients was only tested after transplantation; if recipients of a deceased donor subsequently developed B19V infection, the serum viral load of recipients and their corresponding donors before transplantation would then be further traced.ResultsA total of 15 living donors were B19V DNAemia positive before the donation, of which B19V DNAemia occurred in three corresponding recipients. In deceased donor kidney transplantation, DNAemia occurred simultaneously in 18 recipients and their corresponding nine donors. A progressive decline in hemoglobin and reticulocyte count could be observed in one living donor recipient and other 11 deceased donor recipients, which were all well controlled by treatment eventually.ConclusionThe incidence of donor-derived B19V infection was 0.4% and 1.5% in living and deceased kidney transplantations, respectively. B19V was seemingly unnecessary to be routinely screened for the donor. Moreover, kidneys of the donors with B19V infection were acceptable.
Keywords
- kidney transplantation
- living donor
- deceased donor
- pure red cell aplasia (PRCA)
- human parvovirus B19
