Viral load in chronic hepatitis b: correlation with laboratory and morphological parameters

Abstract

In our study, 155 patients with chronic hepatitis B viral load was analyzed and its relationship with some of the results of laboratory and instrumental examinations. Found that half of the patients had a viral load of 4-5 log copies/ ml and above. In HBe-negative patients, the viral load is lower than in patients with HBeAg. The level of viremia had a direct correlation with the activity of ALT and AST, and eedback to the level of blood platelets. In patients with a viral load of more than 5 log copies / ml, significantly higher ALT, AST and GGT, as well as the level of red blood cells, whereas platelet counts were significantly lower than in patients with viremia <5 log copies/ml . Platelet counts inversely correlated with age. In 11% of patients with chronic hepatitis B over 40 years, had platelet counts below normal. The level of viral load and ALT and AST is straight, and the level of blood platelets inverse correlation with the severity of liver fibrosis. In patients without evidence of liver fibrosis (F0) viral load was significantly lower than in patients with signs of fibrosis of the liver at any stage of its formation.

Keywords

• хронический гепатит в
• вирусная нагрузка.