Lipids in Health and Disease (Nov 2022)

Lp(a), oxidized phospholipids and oxidation-specific epitopes are increased in subjects with keloid formation

  • Sundeep Ruder,
  • Brett Mansfield,
  • Andrew Ronald Immelman,
  • Nissi Varki,
  • Phuong Miu,
  • Frederick Raal,
  • Sotirios Tsimikas

DOI
https://doi.org/10.1186/s12944-022-01720-z
Journal volume & issue
Vol. 21, no. 1
pp. 1 – 8

Abstract

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Highlights Keloid formation is common among individuals of African ancestry. Lp(a) and OxPL are associated with acute and chronic CVD events. Lp(a) and OxPL-apoB levels are elevated in patients with keloids. Keloids express OxPL staining but not Lp(a) staining. OxPL on Lp(a) may be mechanistically involved in keloid formation.