Nature Communications (Aug 2019)
PTPσ inhibitors promote hematopoietic stem cell regeneration
- Yurun Zhang,
- Martina Roos,
- Heather Himburg,
- Christina M. Termini,
- Mamle Quarmyne,
- Michelle Li,
- Liman Zhao,
- Jenny Kan,
- Tiancheng Fang,
- Xiao Yan,
- Katherine Pohl,
- Emelyne Diers,
- Hyo Jin Gim,
- Robert Damoiseaux,
- Julian Whitelegge,
- William McBride,
- Michael E. Jung,
- John P. Chute
Affiliations
- Yurun Zhang
- Molecular Biology Institute, University of California, Los Angeles (UCLA)
- Martina Roos
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Heather Himburg
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Christina M. Termini
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Mamle Quarmyne
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Michelle Li
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Liman Zhao
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Jenny Kan
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Tiancheng Fang
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Xiao Yan
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Katherine Pohl
- Division of Hematology/Oncology, Department of Medicine, UCLA
- Emelyne Diers
- Department of Chemistry and Biochemistry, UCLA
- Hyo Jin Gim
- Department of Chemistry and Biochemistry, UCLA
- Robert Damoiseaux
- Jonsson Comprehensive Cancer Center, UCLA
- Julian Whitelegge
- Department of Psychiatry and Behavioral Sciences, UCLA
- William McBride
- Jonsson Comprehensive Cancer Center, UCLA
- Michael E. Jung
- Department of Chemistry and Biochemistry, UCLA
- John P. Chute
- Division of Hematology/Oncology, Department of Medicine, UCLA
- DOI
- https://doi.org/10.1038/s41467-019-11490-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC pathway and BCL-XL.
