Nature Communications (Aug 2021)

The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy

  • Shayne E. Quinn,
  • Lu Huang,
  • Jason G. Kerkvliet,
  • Joel A. Swanson,
  • Steve Smith,
  • Adam D. Hoppe,
  • Robert B. Anderson,
  • Natalie W. Thiex,
  • Brandon L. Scott

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12


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Macropinocytosis is a cellular process for the uptake of extracellular fluid. Here, the authors use lattice light sheet microscopy to examine the spatial dynamics of the plasma membrane, PI3K activity, and structural differences of various macrophage cell types during macropinocytosis.