Association between dietary calcium to Phosphorus Ratio and the odds of ulcerative colitis: A case-control study
Hadith Tangestani,
Ali Jamshidi,
Zahra Yari,
Zahrasadat Jalaliyan,
Hamid Ghalandari,
Azita Hekmatdoost,
Samaneh Rashvand,
Amirhossein Mohammadi Baghmolae,
Hadi Emamat
Affiliations
Hadith Tangestani
Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
Ali Jamshidi
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Zahra Yari
Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences Tehran, Tehran, Iran
Zahrasadat Jalaliyan
School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Hamid Ghalandari
Department of Community Nutrition, Shiraz University of Medical Sciences Shiraz University of Medical Sciences, Shiraz, Iran
Azita Hekmatdoost
Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Samaneh Rashvand
Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amirhossein Mohammadi Baghmolae
Students Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
Hadi Emamat
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran; Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran; Corresponding author. Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran.
Background & aims: Ulcerative colitis (UC) is a recurrent, inflammatory, autoimmune intestinal disease. The dietary calcium to phosphorus (Ca:P) ratio is suggested to affect the inividuals’ normal metabolic and inflammatory pathways. The present study aimed to investigate the association between dietary Ca:P ratio and the odds of developing UC in a case-control format. Methods: The study included sixty-two currently diagnosed UC patients and one hundred twenty-four matched controls, designed as a case-control study. The dietary intakes of the participants were assessed by a food frequency questionnaire (FFQ), and the dietary Ca:P ratio was calculated. The association between tertiles of Ca:P ratio and UC was examined using the logistic regression. P-values <0.05 were considered as significant. Results: The study sample consisted of participants with an average age of 36.63 ± 12.42 years and a mean body mass index (BMI) of 25.39 ± 3.82 kg/m2. The overall energy-adjusted ratio of Ca:P was 0.74 ± 0.11. In the multivariate model, after adjustment for potential confounders, participants in the third tertile of dietary Ca:P ratio had a lower odds of developing UC compared to the lowest tertlie (OR: 0.34, 95% CI: 0.13–0.87; p = 0.026). Conclusion: Our results indicate that a higher ratio of dietary Ca:P ratio might be protective against developing UC. However, further studies are warranted to examine this association in various populations.
