Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice
Pei-Yi Chu,
Chang-Lu Hsu,
Yen-An Lin,
Yi-Cheng Pan,
Yun-Hao Dai,
Ying-Chun Yu,
Juan-Cheng Yang,
Wen-Lung Ma,
Yi-Jinn Lillian Chen,
Chia-Lin Lee,
Yang-Chang Wu
Affiliations
Pei-Yi Chu
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan
Chang-Lu Hsu
Department of Business Administration, National Chiayi University, Chiayi, Taiwan
Yen-An Lin
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
Yi-Cheng Pan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; .Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan
Yun-Hao Dai
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; School of Pharmacy, China Medical University, Taichung, Taiwan
Ying-Chun Yu
Department of Medical Research, and Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan
Juan-Cheng Yang
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
Wen-Lung Ma
Department of Medical Research, and Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan
Yi-Jinn Lillian Chen
Department of Physics, National Kaohsiung Normal University, Kaohsiung, Taiwan
Chia-Lin Lee
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; Department of Cosmeceutics, China Medical University, Taichung 40604, Taiwan; Corresponding author. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
Yang-Chang Wu
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan; Corresponding author. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
The present study investigated the potential anti-obesity properties of Citrus depressa Hayata (CDH) juice in HBV transgenic mice, as well as the impact of fermentation on the effectiveness of the juice. The results revealed that fermentation increased the levels of polyphenols and hesperidin in CDH juice. The animal study demonstrated that both juices were effective in mitigating the weight gain induced by a high-fat diet by correcting metabolic parameter imbalances, reducing hepatic lipid accumulation, and reversing hepatic immune suppression. Furthermore, fermented juice exhibited superior efficacy in managing body weight and inhibiting the expansion of white adipose tissue (WAT). Fermented juice significantly enhanced adiponectin production and PPARγ expression in WAT, while also reducing hypertrophy. This study offers valuable insights into the potential role of CDH juices in combating obesity associated with high fat consumption and underscores the promise of CDH juice as a functional beverage.
