Nature Communications (Oct 2018)

Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen

  • Mathieu Deygas,
  • Rudy Gadet,
  • Germain Gillet,
  • Ruth Rimokh,
  • Philippe Gonzalo,
  • Ivan Mikaelian

DOI
https://doi.org/10.1038/s41467-018-06988-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient in mammary cells.