P.12 Investigating the Role of Glycemic Markers in Pulse Pressure Amplification in Young Adults: The African-PREDICT Study

Abstract

Objective: Pulse pressure amplification (PPA) is described as the amplification of pulse pressure from central arteries to the periphery [1] and individuals with a decreased PPA have an increased risk of cardiovascular disease [2]. Adverse changes in PPA are evident in diabetic populations [3]; however, it is unclear whether PPA differs along varying degrees of glycaemia in young healthy populations. We therefore investigated whether PPA is attenuated with higher levels of glycemic markers and whether PPA is associated with glycemic markers independent of other known risk factors. Methods: We included 1195 men and women from the African-PREDICT study, aged 20–30 years, with no prior diagnosis of chronic disease. We determined supine central PP (cPP) using the SphygmoCor XCEL device and PPA was defined as the ratio of the amplitude of the PP between the distal and proximal locations (bPP/cPP). Fasting glucose and glycated haemoglobin were determined and the study population was stratified by tertiles of each glycemic marker. Results: The mean PPA was lower in the highest tertile of fasting glucose when compared to the lowest tertile (1.11 vs. 1.23; p ≤ 0.001). PPA declined with increasing levels of fasting glucose (p–trend ≤ 0.001) after adjustment for age, sex, ethnicity, height, heart rate and mean arterial pressure. In multivariable adjusted regression, we found an independent inverse association between PPA and fasting glucose (β = −0.15, p ≤ 0.001). Conclusion: PPA decreases with an increase in fasting glucose in adults younger than 30 years, exemplifying early vascular changes which may increase future cardiovascular risk. FigurePulse pressure amplification plotted against tertiles of fasting glucose. Values are adjusted for age, sex, heart rate, height and mean arterial pressure. *indicates p-value < 0.05 between the lowest and highest glucose group. Adjusted R2 Pulse pressure amplification 0.15 β (SE) p Age (years) –0.17 (0.03) <0.001 Sex 0.10 (0.04) 0.023 Ethnicity 0.02 (0.03) 0.573 Height (cm) 0.13 (0.04) 0.005 Waist circumference (cm) –0.06 (0.03) 0.150 Mean arterial pressure (mmHg) 0.17 (0.03) <0.001 Heart rate (bpm) 0.10 (0.03) <0.001 LDL-c (mmol/L) –0.04 (0.03) 0.179 Fasting glucose (mmol/L) –0.15 (0.03) <0.001 Total energy expenditure (kCal) 0.06 (0.04) 0.091 Self-reported smoking (%) –0.01 (0.02) 0.809 Self-reported alcohol use (%) –0.03 (0.02) 0.350 Data expressed as beta-values and standard errors. LDL-c, low-density lipoprotein cholesterol. p-values ≤ 0.05 regarded as significant. TableForward stepwise multiple regression analyses between PPA and fasting glucose

Keywords

• Pulse pressure ratio
• diabetes