Nature Communications (Jan 2016)
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
Abstract
HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.