Nature Communications (Jan 2016)

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

  • Yunho Kim,
  • Hye Jin Nam,
  • Junyeop Lee,
  • Do Young Park,
  • Chan Kim,
  • Young Suk Yu,
  • Dongha Kim,
  • Se Won Park,
  • Jinhyuk Bhin,
  • Daehee Hwang,
  • Ho Lee,
  • Gou Young Koh,
  • Sung Hee Baek

DOI
https://doi.org/10.1038/ncomms10347
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.