Nature Communications (Sep 2021)

β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture

  • Syed Raza Mahmood,
  • Xin Xie,
  • Nadine Hosny El Said,
  • Tomas Venit,
  • Kristin C. Gunsalus,
  • Piergiorgio Percipalle

DOI
https://doi.org/10.1038/s41467-021-25596-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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β-actin loss can affect gene expression and heterochromatin organization. Here the authors conduct a comprehensive genomic analysis of β-actin knockout mouse embryonic fibroblasts (MEFs) to investigate the impact of changes in β-actin levels on 3d genome architecture and chromatin remodeling activities of BAF and polycomb proteins.