High-Efficiency Adsorption of SARS-CoV-2 Spike 1 Protein by Plasma-Modified Porous Polymers

Abstract

Under the background of the COVID-19 pandemic, this study reports an affordable and easily prepared porous material modified by nanosecond-pulsed discharge plasma, which can adsorb SARS-CoV-2 S1 protein efficiently. Both Western blotting and an enzyme-linked immunosorbent assay were used to detect the adsorption efficiency of SARS-CoV-2 S1 protein. The physical and chemical properties of the modified porous polymer were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. We found that the new type of porous polymer material presented an excellent performance on SARS-CoV-2 S1 protein adsorption, whose adsorption efficiency reached 99.99% in 1 min. Both the physical and chemical characterizations showed that the material has many fresh pores on the material surface and that the surface is implanted with polar functional groups (C−O, C=O, O−C=O and −NH), which gives the material a high chemisorption performance along with an enhanced physical adsorption performance. Notably, the material can be prepared at prices ranging in the tens of dollars per kilogram, which shows that it could have great applications for respiratory virus protection in global epidemic states.

Keywords

• SARS-CoV-2 S1 protein
• protein adsorption
• nanosecond pulsed discharge
• modified porous polymers