Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients

Abstract

Both hypothyroidism and hyperthyroidism affect renal function. The aim of this study was to investigate the relationship between parameters of thyroid function (TSH, free triiodothyronine (FT3), and free thyroxine (FT4)) and parameters of renal function in patients with type 1 diabetes (T1DM). The study included 272 T1DM with normoalbuminuria and estimated glomerular filtration rate (eGFR) > 60 ml/min-11.73m-2, normal thyroid function, and without antihypertensive and antihyperlipidemic therapy. TSH significantly correlated with urinary albumin excretion rate (UAE) (r=-0.15, p 60 ml/min-11.73m-2 without therapeutic intervention, suggests that the thyroid function may be connected with renal function parameters even in the euthyroid range.

Keywords

• Thyroid hormones
• Type 1 diabetes
• Renal function
• Albuminuria