ANTIHELMINTHIC ACTIVITY OF GETIRYAMIDES 1,4-DECARBOXYLIC ACIDS

Abstract

Antihelminthic potency 10-getiryamides 1,4-decarboxylic acids was analyzed. 5 mL of 0.5% aqueous solution of investigated substances was placed in the Petrie dish and earthworms were immersed in a solution. Time of death of each species was determined according to the cessation of motion activity in response to mechanical irritation. Antihelminthic products Pirantel and Levomizol were used as references. Three substances have an antihelminthic effect exceeding the activity of Pirantel, one of them is twice as active as Levomizol.

Keywords

• getiryamides
• 1,4-decarboxylic acids
• antihelminthic activity