Do you know what I’m thinking? Temporal and spatial brain activity during a theory-of-mind task in children with autism

Veronica Yuk; Charline Urbain; Elizabeth W. Pang; Evdokia Anagnostou; Daphna Buchsbaum; Margot J. Taylor

Developmental Cognitive Neuroscience (Nov 2018)

Do you know what I’m thinking? Temporal and spatial brain activity during a theory-of-mind task in children with autism

Veronica Yuk,
Charline Urbain,
Elizabeth W. Pang,
Evdokia Anagnostou,
Daphna Buchsbaum,
Margot J. Taylor

Affiliations

Veronica Yuk: Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada; Corresponding author at: Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Charline Urbain: Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Elizabeth W. Pang: Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
Evdokia Anagnostou: Department of Neurology, The Hospital for Sick Children, Toronto, ON, Canada; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada
Daphna Buchsbaum: Department of Psychology, University of Toronto, Toronto, ON, Canada
Margot J. Taylor: Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada

Journal volume & issue: Vol. 34
pp. 139 – 147

Abstract

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The social impairments observed in children with autism spectrum disorder are thought to arise in part from deficits in theory of mind, the ability to understand other people’s thoughts and feelings. To determine the temporal-spatial dynamics of brain activity underlying these atypical theory-of-mind processes, we used magnetoencephalography to characterize the sequence of functional brain patterns (i.e. when and where) related to theory-of-mind reasoning in 19 high-functioning children with autism compared to 22 age- and sex-matched typically-developing children aged 8–12 during a false-belief (theory-of-mind) task. While task performance did not differ between the two groups, children with autism showed reduced activation in the left temporoparietal junction between 300–375 and 425–500 ms, as well as increased activation in the right inferior frontal gyrus from 325 to 375 ms compared to controls. The overlap in decreased temporoparietal junction activity and increased right inferior frontal gyrus activation from 325 to 375 ms suggests that in children with autism, the right inferior frontal gyrus may compensate for deficits in the temporoparietal junction, a neural theory-of-mind network hub. As the right inferior frontal gyrus is involved in inhibitory control, this finding suggests that children with autism rely on executive functions to bolster their false-belief understanding. Keywords: Autism, Children, False belief, Magnetoencephalography, Theory of mind

Published in Developmental Cognitive Neuroscience

ISSN: 1878-9293 (Print); 1878-9307 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physiology: Neurophysiology and neuropsychology
Website: http://www.journals.elsevier.com/developmental-cognitive-neuroscience/

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