Вестник войск РХБ защиты (Jul 2023)
Statutory, legal, scientific and productive aspects of conditions and prospects of development of antidote therapy in the Russian Federation
Abstract
The modern period in the development of the world community and the Russian Federation in particular is characterized by the globalization of chemical danger. The increase of chemical hazards is determined by the growing potential of the chemical industry in developed countries, widespread use of highly toxic substances in industry, presence of not destroyed stockpiles of chemical weapons abroad, bolstering terrorist manifestations etc. In these circumstances one of the components of the concept of medical support for chemical safety is the existence of a scientifically based system for the development and application of medical technologies for the treatment and prophylaxis of chemical poisoning. The system of emergency specialized toxicological assistance that exists in the Russian Federation suggests the use of means of antidote therapy. However, the analysis of the reports of centers / departments of acute poisoning indicates the lack of significant means of specific pharmacotherapy there. Also there are no important antidotes to cyanides, irritants or alcohol substitutes on Russia's pharmaceutical market. After the analysis of the state of the scientific, technological and industrial base, as well as the analysis of the potential hazards of a chemical nature, it is necessary to underline, that the main directions for the optimization of the antidote therapy system in the Russian Federation should include experimental and clinical studies aimed at the development and creation of innovative antidotes (or adaptation and licensing of various pharmacopeial drugs). The short-term tasks of research, production and regulatory development of the antidote therapy system in the Russian Federation are connected with the completion of the development, registration and acceptance of domestic means of antidote therapy (antidotes to cyanides, combustion products, irritants, psychodisleptics), improvement of technical means of applying existing antidotes, legal regulations in the sphere of providing access to antidotes for medical units and organizations.
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