Interaction of Electromagnetic Field and Modulation of GABA-B Receptor on Serum Testosterone Concentration in Aggressive Rats

Abstract

Introduction: The aim of the present study is to investigate the effect of interaperitoneal injection of baclofen (GABA-B agonist) and CGP35348 (GABA-B antagonist) on serum testosterone concentration in aggressive rats exposed to electromagnetic field. Methods: Fifty five mature male rats weighing 200±20 grams were studied. Animals were divided into 2 main groups and four subgroups. Main groups composed of rats with and without exposure to electromagnetic field. Animals in the former group were exposed to electromagnetic field with 500 T intensity and 50Hz frequency for 8 hours a day for 30 days. Aggression was induced by applying 2mA current every 3 seconds for 5 minutes. Then serum testosterone concentration was measured by radioimmunoassay method. Results: Data showed that baclofen injection at 3mg/kg and CGP35348 at 100mg/kg significantly increased serum testosterone concentration in aggressive rats exposed to electromagnetic field. Conclusion: According to the simillar effect of baclofen and CGP35348 on testosterone secretion, it seems that GABA-B receptors in testes are two types, so it has caused similar effects. Also, electromagnetic exposure leads to increase in testosterone secretion.

Keywords

• Electromagnetic Phenomena/adverse effects
• Baclofen
• Receptors
• GABA-B
• Aggression/Phisiology
• Mice
• Testosterone