Nature Communications (Oct 2017)
Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
- Elisabetta Aloisi,
- Katy Le Corf,
- Julien Dupuis,
- Pei Zhang,
- Melanie Ginger,
- Virginie Labrousse,
- Michela Spatuzza,
- Matthias Georg Haberl,
- Lara Costa,
- Ryuichi Shigemoto,
- Anke Tappe-Theodor,
- Filippo Drago,
- Pier Vincenzo Piazza,
- Christophe Mulle,
- Laurent Groc,
- Lucia Ciranna,
- Maria Vincenza Catania,
- Andreas Frick
Affiliations
- Elisabetta Aloisi
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- Katy Le Corf
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- Julien Dupuis
- Interdisciplinary Institute for Neuroscience, IINS-CNRS, UMR 5297, University of Bordeaux
- Pei Zhang
- Interdisciplinary Institute for Neuroscience, IINS-CNRS, UMR 5297, University of Bordeaux
- Melanie Ginger
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- Virginie Labrousse
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- Michela Spatuzza
- Institute of Neurological Sciences, National Research Council, ISN-CNR
- Matthias Georg Haberl
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- Lara Costa
- Department of Clinical and Experimental Medicine, University of Messina
- Ryuichi Shigemoto
- IST Austria
- Anke Tappe-Theodor
- Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366
- Filippo Drago
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Pier Vincenzo Piazza
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- Christophe Mulle
- Interdisciplinary Institute for Neuroscience, IINS-CNRS, UMR 5297, University of Bordeaux
- Laurent Groc
- Interdisciplinary Institute for Neuroscience, IINS-CNRS, UMR 5297, University of Bordeaux
- Lucia Ciranna
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Maria Vincenza Catania
- Institute of Neurological Sciences, National Research Council, ISN-CNR
- Andreas Frick
- INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215
- DOI
- https://doi.org/10.1038/s41467-017-01191-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Dysfunction of mGluR5 has been implicated in Fragile X syndrome. Here, using a single-molecule tracking technique, the authors found an increased lateral mobility of mGluR5 at the synaptic site in Fmr1 KO hippocampal neurons, leading to abnormal NMDAR-mediated synaptic plasticity and cognitive deficits.
