Clinical Epidemiology and Global Health (Mar 2022)

The impact of casirivimab-imdevimab antibody cocktail in patients amidst and post COVID 19 treatment: A retro-prospective comparative study in India

  • Aneesh Puthiyedath Joy,
  • Anitha Theresa Augustine,
  • Mohammed Salim Karattuthodi,
  • Jaffer Chalil Parambil,
  • Dilip Chandrasekher,
  • P. Danisha,
  • Linu Mohan Panakkal,
  • Madhav A. Joshi,
  • K.T. Azharul Haque,
  • Irshad K. Mohammed Izudheen,
  • Shadia Badaruddeen,
  • Riya Sara John,
  • Sarath Murali,
  • Ardhra Rose Thomas,
  • Fathimath Sahla,
  • Shahir Ahmed KV. Ahmed Unni,
  • Raseel Omar Ahmed,
  • Shinu Cholamugath

Journal volume & issue
Vol. 14
p. 100967

Abstract

Read online

Background: Monoclonal antibodies have gained attention in developing countries owing to its benefits portrayed by few clinical trials. However, no studies until now have been undergone in India. Methods: A retro-prospective comparative observational study was conducted in symptomatic COVID19 patients to evaluate the impact of Casirivimab and Imdevimab antibody cocktail in the high-risk population. Through an extensive data retrieval for 6 months, 152 samples were documented and sorted into test (Casirivimab and Imdevimab treated patients, n = 79) and control (Non- Casirivimab and Imdevimab treated individuals, n = 73) subsets. The research had two phases; first, estimation of mechanical ventilation and high flow oxygen requirement and mortality in samples amidst the treatment, and second was the post COVID19 patients' feedback through validated (Cronbach's alpha coefficient = 0.7) questionnaire that evaluated their health and vaccination status, and treatment satisfaction. Results: We noticed lesser requisite for mechanical ventilation (6.3%; p < 0.001), high flow oxygen (5.1%; p < 0.001) and no death during Casirivimab and Imdevimab therapy. Meanwhile, non-vaccinated test groups were not on mechanical ventilation and those fully immunized seldom entailed high flow oxygen (test, 6.3%; control, 41.9%, p < 0.01). On evaluating the post COVID19 status of each patient in the study, 90.1% of the test samples were healthy and 97.2% were satisfied with the treatment than those in control group. Conclusions: Casirivimab and Imdevimab regimen was clinically beneficial for high risk COVID19 patients than those treated without the antibody cocktail.

Keywords