Correlation between PD-L1 Expression of Non-Small Cell Lung Cancer and Data from IVIM-DWI Acquired during Magnetic Resonance of the Thorax: Preliminary Results

Chandra Bortolotto; Giulia Maria Stella; Gaia Messana; Antonio Lo Tito; Chiara Podrecca; Giovanna Nicora; Riccardo Bellazzi; Alessia Gerbasi; Francesco Agustoni; Robert Grimm; Domenico Zacà; Andrea Riccardo Filippi; Olivia Maria Bottinelli; Lorenzo Preda

doi:10.3390/cancers14225634

Cancers (Nov 2022)

Correlation between PD-L1 Expression of Non-Small Cell Lung Cancer and Data from IVIM-DWI Acquired during Magnetic Resonance of the Thorax: Preliminary Results

Chandra Bortolotto,
Giulia Maria Stella,
Gaia Messana,
Antonio Lo Tito,
Chiara Podrecca,
Giovanna Nicora,
Riccardo Bellazzi,
Alessia Gerbasi,
Francesco Agustoni,
Robert Grimm,
Domenico Zacà,
Andrea Riccardo Filippi,
Olivia Maria Bottinelli,
Lorenzo Preda

Affiliations

Chandra Bortolotto: Diagnostic Imaging and Radiotherapy Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Giulia Maria Stella: Unit of Respiratory Diseases, Department of Medical Sciences and Infective Diseases, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Gaia Messana: Diagnostic Imaging and Radiotherapy Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Antonio Lo Tito: Diagnostic Imaging and Radiotherapy Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Chiara Podrecca: Department of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100 Pavia, Italy
Giovanna Nicora: Department of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100 Pavia, Italy
Riccardo Bellazzi: Department of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100 Pavia, Italy
Alessia Gerbasi: Department of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100 Pavia, Italy
Francesco Agustoni: Department of Medical Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Robert Grimm: MR Application Predevelopment, Siemens Healthcare GmbH, 91052 Erlangen, Germany
Domenico Zacà: Siemens Healthcare, 20128 Milano, Italy
Andrea Riccardo Filippi: Diagnostic Imaging and Radiotherapy Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Olivia Maria Bottinelli: Diagnostic Imaging and Radiotherapy Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Lorenzo Preda: Diagnostic Imaging and Radiotherapy Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy

DOI: https://doi.org/10.3390/cancers14225634
Journal volume & issue: Vol. 14, no. 22
p. 5634

Abstract

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This study aims to investigate the correlation between intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters in magnetic resonance imaging (MRI) and programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC). Twenty-one patients diagnosed with stage III NSCLC from April 2021 to April 2022 were included. The tumors were distinguished into two groups: no PD-L1 expression (4 in no PD-L1 expression vs. 122.0 ± 31.306 µm²/s × 104 in positive PD-L1 expression, p = 0.008). The values obtained with algorithms 1, 2, and 3 were not significantly different between the groups. The IVIM-DWI MRI parameter D* can reflect PD-L1 expression in NSCLC.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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