Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

Alessandro Bertero; Paul A. Fields; Vijay Ramani; Giancarlo Bonora; Galip G. Yardimci; Hans Reinecke; Lil Pabon; William S. Noble; Jay Shendure; Charles E. Murry

doi:10.1038/s41467-019-09483-5

Nature Communications (Apr 2019)

Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

Alessandro Bertero,
Paul A. Fields,
Vijay Ramani,
Giancarlo Bonora,
Galip G. Yardimci,
Hans Reinecke,
Lil Pabon,
William S. Noble,
Jay Shendure,
Charles E. Murry

Affiliations

Alessandro Bertero: Department of Pathology, University of Washington
Paul A. Fields: Department of Pathology, University of Washington
Vijay Ramani: Department of Genome Sciences, University of Washington
Giancarlo Bonora: Department of Genome Sciences, University of Washington
Galip G. Yardimci: Department of Genome Sciences, University of Washington
Hans Reinecke: Department of Pathology, University of Washington
Lil Pabon: Department of Pathology, University of Washington
William S. Noble: Department of Genome Sciences, University of Washington
Jay Shendure: Department of Genome Sciences, University of Washington
Charles E. Murry: Department of Pathology, University of Washington

DOI: https://doi.org/10.1038/s41467-019-09483-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 19

Abstract

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The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other RBM20 targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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