Nature Communications (Nov 2017)

Development of a genetic sensor that eliminates p53 deficient cells

  • Jovan Mircetic,
  • Antje Dietrich,
  • Maciej Paszkowski-Rogacz,
  • Mechthild Krause,
  • Frank Buchholz

DOI
https://doi.org/10.1038/s41467-017-01688-w
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene, which can activate the drug Ganciclovir, resulting in cell death.