Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors

Jingjing Liang; Jun Lyu; Meng Zhao; Dan Li; Mingzhu Zheng; Yan Fang; Fangzhu Zhao; Jun Lou; Chuansheng Guo; Lie Wang; Di Wang; Wanli Liu; Linrong Lu

doi:10.1038/ncomms15732

Nature Communications (Jun 2017)

Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors

Jingjing Liang,
Jun Lyu,
Meng Zhao,
Dan Li,
Mingzhu Zheng,
Yan Fang,
Fangzhu Zhao,
Jun Lou,
Chuansheng Guo,
Lie Wang,
Di Wang,
Wanli Liu,
Linrong Lu

Affiliations

Jingjing Liang: Institute of Immunology, Zhejiang University School of Medicine
Jun Lyu: Institute of Immunology, Zhejiang University School of Medicine
Meng Zhao: Ministry of Education Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University
Dan Li: Institute of Immunology, Zhejiang University School of Medicine
Mingzhu Zheng: Institute of Immunology, Zhejiang University School of Medicine
Yan Fang: Ministry of Education Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University
Fangzhu Zhao: Institute of Immunology, Zhejiang University School of Medicine
Jun Lou: Institute of Immunology, Zhejiang University School of Medicine
Chuansheng Guo: Institute of Immunology, Zhejiang University School of Medicine
Lie Wang: Institute of Immunology, Zhejiang University School of Medicine
Di Wang: Institute of Immunology, Zhejiang University School of Medicine
Wanli Liu: Ministry of Education Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University
Linrong Lu: Institute of Immunology, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/ncomms15732
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The thymocyte development protein Tespa1 is known to translate T cell receptor signals by affecting the calcium signalling cascade, but it is not clear how. Here the authors show that Tespa1 recruits IP3R1 to the TCR signalling complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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