A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration

Julia Löffler; Anne Noom; Agnes Ellinghaus; Anke Dienelt; Stefan Kempa; Georg N. Duda

doi:10.1038/s42003-023-04652-1

Communications Biology (Mar 2023)

A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration

Julia Löffler,
Anne Noom,
Agnes Ellinghaus,
Anke Dienelt,
Stefan Kempa,
Georg N. Duda

Affiliations

Julia Löffler: Julius Wolff Institute (JWI), Berlin Institute of Health at Charité—Universitätsmedizin Berlin
Anne Noom: Julius Wolff Institute (JWI), Berlin Institute of Health at Charité—Universitätsmedizin Berlin
Agnes Ellinghaus: Julius Wolff Institute (JWI), Berlin Institute of Health at Charité—Universitätsmedizin Berlin
Anke Dienelt: Julius Wolff Institute (JWI), Berlin Institute of Health at Charité—Universitätsmedizin Berlin
Stefan Kempa: Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine
Georg N. Duda: Julius Wolff Institute (JWI), Berlin Institute of Health at Charité—Universitätsmedizin Berlin

DOI: https://doi.org/10.1038/s42003-023-04652-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 17

Abstract

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Metabolites are demonstrated to be critical regulators of fracture healing. Succinate is found to promote vascularization and ossification, highlighting that metabolites have the potential to be used therapeutically to promote fracture healing.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal