Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus
Deming Tang,
Asaiti Bukai,
Shuai Qin,
Ran Duan,
Dongyue Lyu,
Zhaokai He,
Xiaojin Zheng,
Weiwei Wu,
Junrong Liang,
Haifu Qu,
Aidai Bieke,
Peng Zhang,
Dan Zhang,
Haonan Han,
Qun Duan,
Huaiqi Jing,
Xin Wang
Affiliations
Deming Tang
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Dongcheng Center for Disease Control and Prevention, Beijing, China
Asaiti Bukai
Akesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, China
Shuai Qin
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Ran Duan
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Dongyue Lyu
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Zhaokai He
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Xiaojin Zheng
Akesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, China
Weiwei Wu
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Junrong Liang
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Haifu Qu
Akesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, China
Aidai Bieke
Akesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, China
Peng Zhang
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Dan Zhang
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Haonan Han
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Qun Duan
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Huaiqi Jing
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Xin Wang
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Corresponding author.
In this study, we investigated the F1 antibody against Yersinia pestis in the sera of mother-neonate shepherd dog pairs in the Marmota himalayana plague focus of the Altun-Qilian Mountains, Qinghai-Tibetan Plateau, China. Seropositive shepherd dogs lived in plague-endemic regions, where marmots were infected with Y. pestis, whereas seronegative dogs lived in non-endemic regions. The neonatal F1 antibody titers positively correlated with the maternal titers within 3 months after birth, and the neonatal titers were similar to or slightly lower than the maternal titers. In the absence of reinfection, antibodies in the neonates were obtained from their mothers; titers decreased with age and disappeared after 3 months. Mean tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-2, IL-10, and nerve growth factor (NGF)-β were higher in the mothers than in neonates. Maternal TNF-α, IL-10, vascular endothelial growth factor (VEGF)-A, and NGF-β and neonatal monocyte chemoattractant factor (MCP)-1 and VEGF-A were positively correlated with F1 antibody titers. Our results reveal continuing vertical transmission of F1 antibodies between mother dogs and their offspring and cytokine signatures under plague.
