Clinical Medicine Insights: Case Reports (May 2023)

Bifocal Intracanial Rosai-Dorfman Disease Mimicking Lymphoplasmacyte-Rich Meningioma: Diagnostic Pitfalls About a Case Report

  • Hafsa El Ouazzani,
  • Firdaous Touarsa,
  • Zaynab Iraqui Houssaini,
  • Mahdi Hakkou,
  • Mohammed Yasaad Elouadghiri,
  • Abdessamad Ouhabi,
  • Mohamed Jiddane,
  • Fouad Zouaidia,
  • Nadia Cherradi

DOI
https://doi.org/10.1177/11795476231172354
Journal volume & issue
Vol. 16

Abstract

Read online

Rosai-Dorfman disease (RDD) is a clonal histiocytic proliferation characterized by large S100 positive histiocytes with variable emperipolesis. Extranodal locations were confirmed with the central nervous system or the meninges involvement in less than 5% of cases, which is marked as a significant differential diagnosis of meningiomas in radiological and intra-operative pathological examination. Histopathology and immunohistochemistry are the keys to definitive diagnosis. We present a case of bifocal Rosai-Dorfman disease in a 26-year-old man, mimicking Lymphoplasmacyte-rich Meningioma. This case allows us to demonstrate the diagnosis pitfalls encountered in this localization.