An Au Nanofilm-Graphene/D-Type Fiber Surface Plasmon Resonance Sensor for Highly Sensitive Specificity Bioanalysis
Xiangtai Xi,
Jihua Xu,
Shuanglu Li,
Jingyi Song,
Wen Yang,
Yang Sun,
Shouzhen Jiang,
Yanshun Han,
Xiuwei Fan
Affiliations
Xiangtai Xi
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Jihua Xu
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Shuanglu Li
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Jingyi Song
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Wen Yang
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Yang Sun
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Shouzhen Jiang
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
Yanshun Han
Qilu Institute of Technology, Jinan 250200, China
Xiuwei Fan
Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China
A highly sensitive Au-graphene structure D-type fiber surface plasmon resonance biosensor is presented in this study to specifically detect biomolecules. The method of growing graphene is employed directly on the copper, and then a gold film of optimum thickness is sputtered, and the copper foil is etched to obtain the structure. This method makes the contact closer between the gold layer and the graphene layer to improve surface plasmon resonance performance. The performance of this type of surface plasmon resonance (SPR) sensor has been previously verified both theoretically and experimentally. With the proposed Au-graphene structure D-type fiber biosensor, the SPR behaviors are obtained and discussed. In the detection of ethanol solution, a red shift of 40 nm is found between the refractive index of 1.3330 and 1.3657. By calculation, the sensitivity of the sensor we designed is 1223 nm/RIU. Besides, the proposed sensor can detect the nucleotide bonding between the double-stranded DNA helix structures. Thus, our sensors can distinguish between mismatched DNA sequences.
