Nature Communications (Sep 2016)
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
- Wen Fong Ooi,
- Manjie Xing,
- Chang Xu,
- Xiaosai Yao,
- Muhammad Khairul Ramlee,
- Mei Chee Lim,
- Fan Cao,
- Kevin Lim,
- Deepak Babu,
- Lai-Fong Poon,
- Joyce Lin Suling,
- Aditi Qamra,
- Astrid Irwanto,
- James Qu Zhengzhong,
- Tannistha Nandi,
- Ai Ping Lee-Lim,
- Yang Sun Chan,
- Su Ting Tay,
- Ming Hui Lee,
- James O. J. Davies,
- Wai Keong Wong,
- Khee Chee Soo,
- Weng Hoong Chan,
- Hock Soo Ong,
- Pierce Chow,
- Chow Yin Wong,
- Sun Young Rha,
- Jianjun Liu,
- Axel M. Hillmer,
- Jim R. Hughes,
- Steve Rozen,
- Bin Tean Teh,
- Melissa Jane Fullwood,
- Shang Li,
- Patrick Tan
Affiliations
- Wen Fong Ooi
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Manjie Xing
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Chang Xu
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Xiaosai Yao
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Muhammad Khairul Ramlee
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Mei Chee Lim
- Cancer Science Institute of Singapore, National University of Singapore
- Fan Cao
- Cancer Science Institute of Singapore, National University of Singapore
- Kevin Lim
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Deepak Babu
- Cancer Science Institute of Singapore, National University of Singapore
- Lai-Fong Poon
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Joyce Lin Suling
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Aditi Qamra
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Astrid Irwanto
- Department of Human Genetics, Genome Institute of Singapore
- James Qu Zhengzhong
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Tannistha Nandi
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Ai Ping Lee-Lim
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Yang Sun Chan
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Su Ting Tay
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Ming Hui Lee
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- James O. J. Davies
- Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University
- Wai Keong Wong
- Department of Upper Gastrointestinal & Bariatric Surgery, Singapore General Hospital
- Khee Chee Soo
- Division of Surgical Oncology, National Cancer Centre Singapore
- Weng Hoong Chan
- Department of Upper Gastrointestinal & Bariatric Surgery, Singapore General Hospital
- Hock Soo Ong
- Department of Upper Gastrointestinal & Bariatric Surgery, Singapore General Hospital
- Pierce Chow
- Division of Surgical Oncology, National Cancer Centre Singapore
- Chow Yin Wong
- Department of General Surgery, Singapore General Hospital
- Sun Young Rha
- Department of Medical Oncology, Yonsei University College of Medicine
- Jianjun Liu
- Department of Human Genetics, Genome Institute of Singapore
- Axel M. Hillmer
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- Jim R. Hughes
- Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University
- Steve Rozen
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Bin Tean Teh
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Melissa Jane Fullwood
- Cancer Science Institute of Singapore, National University of Singapore
- Shang Li
- Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School
- Patrick Tan
- Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
- DOI
- https://doi.org/10.1038/ncomms12983
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.
