Nature Communications (Aug 2017)
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor
- Dirk Roymans,
- Sarhad S Alnajjar,
- Michael B Battles,
- Panchan Sitthicharoenchai,
- Polina Furmanova-Hollenstein,
- Peter Rigaux,
- Joke Van den Berg,
- Leen Kwanten,
- Marcia Van Ginderen,
- Nick Verheyen,
- Luc Vranckx,
- Steffen Jaensch,
- Eric Arnoult,
- Richard Voorzaat,
- Jack M. Gallup,
- Alejandro Larios-Mora,
- Marjolein Crabbe,
- Dymphy Huntjens,
- Pierre Raboisson,
- Johannes P. Langedijk,
- Mark R. Ackermann,
- Jason S McLellan,
- Sandrine Vendeville,
- Anil Koul
Affiliations
- Dirk Roymans
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Sarhad S Alnajjar
- College of Veterinary Medicine, Iowa State University
- Michael B Battles
- Department of Biochemistry, Geisel School of Medicine at Dartmouth
- Panchan Sitthicharoenchai
- College of Veterinary Medicine, Iowa State University
- Polina Furmanova-Hollenstein
- Janssen Vaccines and Prevention
- Peter Rigaux
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Joke Van den Berg
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Leen Kwanten
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Marcia Van Ginderen
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Nick Verheyen
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Luc Vranckx
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Steffen Jaensch
- Computational Biology, Janssen Pharmaceutica NV
- Eric Arnoult
- Computational Chemistry, Janssen R&D LLC
- Richard Voorzaat
- Janssen Vaccines and Prevention
- Jack M. Gallup
- College of Veterinary Medicine, Iowa State University
- Alejandro Larios-Mora
- College of Veterinary Medicine, Iowa State University
- Marjolein Crabbe
- Non-Clinical Statistics, Janssen Pharmaceutica NV
- Dymphy Huntjens
- Clinical Pharmacology and Pharmacometrics, Janssen Pharmaceutica NV
- Pierre Raboisson
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Johannes P. Langedijk
- Janssen Vaccines and Prevention
- Mark R. Ackermann
- College of Veterinary Medicine, Iowa State University
- Jason S McLellan
- Department of Biochemistry, Geisel School of Medicine at Dartmouth
- Sandrine Vendeville
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- Anil Koul
- Janssen Infectious Diseases and Vaccines, Janssen Pharmaceutica NV
- DOI
- https://doi.org/10.1038/s41467-017-00170-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs.
