Nutrients (Jan 2020)
The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review
- María Dolores Mesa,
- Begoña Loureiro,
- Iris Iglesia,
- Sergi Fernandez Gonzalez,
- Elisa Llurba Olivé,
- Oscar García Algar,
- María José Solana,
- Mª Jesús Cabero Perez,
- Talia Sainz,
- Leopoldo Martinez,
- Diana Escuder-Vieco,
- Anna Parra-Llorca,
- María Sánchez-Campillo,
- Gerardo Rodriguez Martinez,
- Dolores Gómez Roig,
- Myriam Perez Gruz,
- Vicente Andreu-Fernández,
- Jordi Clotet,
- Sebastian Sailer,
- Isabel Iglesias-Platas,
- Jesús López-Herce,
- Rosa Aras,
- Carmen Pallás-Alonso,
- Miguel Saenz de Pipaon,
- Máximo Vento,
- María Gormaz,
- Elvira Larqué Daza,
- Cristina Calvo,
- Fernando Cabañas
Affiliations
- María Dolores Mesa
- Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, Armilla, 18100 Granada, Spain
- Begoña Loureiro
- Neonatology Unit, University Hospital Cruces, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain
- Iris Iglesia
- Growth, Exercise, Nutrition and Development (GENUD) Research Group, Universidad de Zaragoza, 50009 Zaragoza, Spain
- Sergi Fernandez Gonzalez
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Elisa Llurba Olivé
- Obstetrics and Gynecology Department, High Risk Unit, Sant Pau University Hospital, 08025 Barcelona, Spain
- Oscar García Algar
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- María José Solana
- Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Departamento de Salud Pública y Materno infantil, Universidad Complutense de Madrid, 28040 Madrid, Spain
- Mª Jesús Cabero Perez
- Hospital Universitario Marqués de Valdecilla, Santander, 39008 Cantabria, Spain
- Talia Sainz
- Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital La Paz, 28046 Madrid, Spain
- Leopoldo Martinez
- Instituto de Investigación Hospital la Paz (IdiPAZ), 28029 Madrid, Spain
- Diana Escuder-Vieco
- Donated Milk Bank, Health Research Institute i + 12, University Hospital 12 de Octubre, Universidad Complutense, 28040 Madrid, Spain
- Anna Parra-Llorca
- Neonatal Research Group, Health Research Institute La Fe, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
- María Sánchez-Campillo
- Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
- Gerardo Rodriguez Martinez
- Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain
- Dolores Gómez Roig
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Myriam Perez Gruz
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Vicente Andreu-Fernández
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Jordi Clotet
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Sebastian Sailer
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Isabel Iglesias-Platas
- BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Sant Joan de Deu and Hospital Clínic), 08028 Barcelona, Spain
- Jesús López-Herce
- Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Departamento de Salud Pública y Materno infantil, Universidad Complutense de Madrid, 28040 Madrid, Spain
- Rosa Aras
- Instituto de Investigación Hospital la Paz (IdiPAZ), 28029 Madrid, Spain
- Carmen Pallás-Alonso
- Donated Milk Bank, Health Research Institute i + 12, University Hospital 12 de Octubre, Universidad Complutense, 28040 Madrid, Spain
- Miguel Saenz de Pipaon
- Department of Neonatology La Paz University Hospital, 28046 Madrid, Spain
- Máximo Vento
- Neonatal Research Group, Health Research Institute La Fe, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
- María Gormaz
- Neonatal Research Group, Health Research Institute La Fe, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
- Elvira Larqué Daza
- Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
- Cristina Calvo
- Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital La Paz, 28046 Madrid, Spain
- Fernando Cabañas
- Department of Paediatrics-Neonatology Quironsalud, Madrid University Hospital and Biomedical Research Foundation-IDIPAZ, La Paz University Hospital, 28046 Madrid, Spain
- DOI
- https://doi.org/10.3390/nu12010133
- Journal volume & issue
-
Vol. 12,
no. 1
p. 133
Abstract
Pregnancy induces a number of immunological, hormonal, and metabolic changes that are necessary for the mother to adapt her body to this new physiological situation. The microbiome of the mother, the placenta and the fetus influence the fetus growth and undoubtedly plays a major role in the adequate development of the newborn infant. Hence, the microbiome modulates the inflammatory mechanisms related to physiological and pathological processes that are involved in the perinatal progress through different mechanisms. The present review summarizes the actual knowledge related to physiological changes in the microbiota occurring in the mother, the fetus, and the child, both during neonatal period and beyond. In addition, we approach some specific pathological situations during the perinatal periods, as well as the influence of the type of delivery and feeding.
Keywords
