Mitochondrial Uncoupling Proteins in the Brain: Their Structure, Function and Physiological Roles [Beyindeki Mitokondriyal Eslesme Bozucu Proteinler: Yapisi, Islevi ve Fizyolojik Rolleri]

Abstract

Uncoupling proteins (UCPs) which belong to mitochondrial anion carrier family are important because of their special distribution to different tissues and their intrinsic physiological function at those tissues. The UCP1 found in the brown fat tissue and being the most well-known member of this family takes in charge for arranging energy metabolism and body temperature. Other members of UCPs family (UCP2, UCP4 and UCP5) demonstrate a broad spread in neural field. Neural UCPs participate in regulating neuroendocrine functions, in forming free radicals production, in conveying neuroprotection and neurotransmission in central nervous system. The aim of this compilation is to provide a better understanding of physiological roles of neural UCPs. [Med-Science 2015; 4(2.000): 2289-307]

Keywords

• Uncoupling proteins
• brain
• mitochondria
• neurodegeneration
• calcium regulation
• oxidative stress