Clinical-Laboratory Parallels in Patients with Demodectic Blepharitis at Cosmecevtic’s Use

Abstract

Purpose. To study the influence of the new cosmecevtic — cream «Demazol» on the dynamics of clinical and laboratory parameters (akarogramms) with Demodex blepharitis.Patients and methods. There were 56 patients with Demodex blepharitis with symptoms of blepharitis or blepharoconjunctivitis in the study. In all cases, the clinical diagnoses were confirmed by laboratory investigations of epilated lashes. The akarogramms indicated the number of adult mite larvae and eggs of parasites separately for each eye. The cream was applied topically on the eyelids 2 times a day following our instructions, and before this, we provided pretreatment alcohol eucalyptus or sage tincture. The course of treatment was 1.5 months. Alongside this, we conducted drug correction of the status of the tear film via artificial tears eyedrops and therapy of blepharitis or blepharoconjunctivitis withantibiotics, steroids or non-steroidal anti-inflammatory drugs. A controlled laboratory testing for the presence of the mite Demodex folliculorum was undertaken after the course of treatment with cream. Evaluation of the efficacy of the cream was undertaken in accordance with the age of patients (up to 70 groups of patients 70 years and older), and the amount of mites.Results. The cosmetic cream «Demazol» had eliminated all forms of the mite Demodex — adults, larvae and eggs of parasites after 45 days of application. The number of mites after the course was significantly reduced: 5.7 times (by the number of adults); 3.7 times (the number of larvae) and 12 times (the number of parasite eggs). Reduction the number of ticks was noted in general by 95% of patients; full or substantial reduction by 62.5%, proving the specific efficacy of «Demazol.» The clinical effect of varying degrees (excluding akarogramm) was noted in 49 of 56 patients (87.5%). The percentage of patients with a moderate pronounced effect from the cream was 78.6%. The combination of a pronounced positive clinical effect with full 100% elimination of mites is recorded at 2/3 of all patients (60.7%). The efficacy of the cream «Demazol» according to clinical symptoms and laboratory parameters (akarogramm) is reduced in patients of an advanced age (over 70 years) and in patients with a high level of initial contamination of ticks or mites, from 5 to 15 on 1 eye. Overall, skin tolerance to the cream was good. Irritation after applying the cream was observed in 5 patients.

Keywords

• demodex blepharitis
• the initial infestation (akarogramma)
• cream «demazol»