不同神经心理症状与脑小血管病影像学关系的研究进展 Research Progress on the Relationship between Various Neuropsychological Symptoms and Imaging of Cerebral Small Vessel Disease

Abstract

脑小血管病（cerebral small vessel disease，CSVD）是由各种病因影响脑内小血管所导致的一系列临床、影像、病理学综合征，其在国际上尚无统一诊断标准，症状轻微，故临床上主要根据神经影像学表现分为新近皮质下小梗死、假定血管源性腔隙、假定血管源性脑白质高信号、血管周围间隙、脑微出血、脑皮质表面铁沉积和脑萎缩。证据表明，CSVD可能与诸多神经心理学症状相关，然而，神经心理症状与CSVD发生和发展之间的关系目前尚不明确。本文对情感淡漠、疲劳、焦虑、抑郁和心理应激与CSVD影像学关系的研究进展进行了综述。 Abstract: Cerebral small vessel disease (CSVD) is a series of clinical, imaging and pathological syndrome caused by various causes affecting the small blood vessels in the brain. There is no unified diagnostic standard in the world for CSVD, and the symptoms are mild. Therefore, based on neuroimaging findings, it can be divided into recent small subcortical infarct, lacune of presumed vascular origin, white matter hyperintensity of presumed vascular origin, perivascular space, cerebral microbleed, cortical superficial siderosis, and brain atrophy. Evidence suggests that CSVD may be associated with a variety of neuropsychological manifestations. However, the relationship between neuropsychological symptoms and the occurrence and development of CSVD is not clear. In this paper, the research progress of the relationship between apathy, fatigue, anxiety, depression and psychological stress and the imaging of CSVD was reviewed.

Keywords

• 脑小血管病
• 神经心理症状
• 影像学特征
• cerebral small vessel disease
• neuropsychological symptom
• imaging feature