Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy

Carles Bosch; Tobias Ackels; Alexandra Pacureanu; Yuxin Zhang; Christopher J. Peddie; Manuel Berning; Norman Rzepka; Marie-Christine Zdora; Isabell Whiteley; Malte Storm; Anne Bonnin; Christoph Rau; Troy Margrie; Lucy Collinson; Andreas T. Schaefer

doi:10.1038/s41467-022-30199-6

Nature Communications (May 2022)

Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy

Carles Bosch,
Tobias Ackels,
Alexandra Pacureanu,
Yuxin Zhang,
Christopher J. Peddie,
Manuel Berning,
Norman Rzepka,
Marie-Christine Zdora,
Isabell Whiteley,
Malte Storm,
Anne Bonnin,
Christoph Rau,
Troy Margrie,
Lucy Collinson,
Andreas T. Schaefer

Affiliations

Carles Bosch: Sensory Circuits and Neurotechnology Lab., The Francis Crick Institute
Tobias Ackels: Sensory Circuits and Neurotechnology Lab., The Francis Crick Institute
Alexandra Pacureanu: Sensory Circuits and Neurotechnology Lab., The Francis Crick Institute
Yuxin Zhang: Sensory Circuits and Neurotechnology Lab., The Francis Crick Institute
Christopher J. Peddie: Electron Microscopy STP, The Francis Crick Institute
Manuel Berning: Department of Connectomics, Max Planck Institute for Brain Research
Norman Rzepka: Scalable minds GmbH
Marie-Christine Zdora: Department of Physics and Astronomy, University College London
Isabell Whiteley: Sensory Circuits and Neurotechnology Lab., The Francis Crick Institute
Malte Storm: Diamond Light Source, Harwell Science and Innovation Campus
Anne Bonnin: Paul Scherrer Institut
Christoph Rau: Diamond Light Source, Harwell Science and Innovation Campus
Troy Margrie: Sainsbury Wellcome Centre, University College London
Lucy Collinson: Electron Microscopy STP, The Francis Crick Institute
Andreas T. Schaefer: Sensory Circuits and Neurotechnology Lab., The Francis Crick Institute

DOI: https://doi.org/10.1038/s41467-022-30199-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

The function of biological tissues is encoded in their physiology and structure. Here, Bosch et al. have integrated both insights to study specific neuronal circuits by combining in vivo light, synchrotron X-ray and volume electron microscopy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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