Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents
Rongping Liu,
Hao Yan,
Jinzhang Jiang,
Jiahe Li,
Xing Liang,
Dengfeng Yang,
Lixia Pan,
Tisan Xie,
Zhen Ma
Affiliations
Rongping Liu
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
Hao Yan
School of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China
Jinzhang Jiang
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
Jiahe Li
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
Xing Liang
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
Dengfeng Yang
Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China
Lixia Pan
National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China
Tisan Xie
School of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China
Zhen Ma
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
Six new zinc(II) complexes were prepared by the reaction of ZnBr2 or ZnI2 with 4′-(substituted-phenyl)-2,2′:6′,2′′-terpyridine compounds, bearing p-methylsulfonyl (L1), p-methoxy (L2) and p-methyl (L3), which were characterized by elemental analysis, FT-IR, NMR and single crystal X-ray diffraction. The antiproliferative properties against Eca-109, A549 and Bel-7402 cell lines and the cytotoxicity test on RAW-264.7 of these compounds were monitored using a CCK-8 assay, and the studies indicate that the complexes show higher antiproliferative activities than cisplatin. The interactions of these complexes with CT-DNA and proteins (BSA) were studied by UV-Vis, circular dichroism (CD) and fluorescent spectroscopy, respectively. The results indicate that the interaction of these zinc(II) complexes with CT-DNA is achieved through intercalative binding, and their strong binding affinity to BSA is fulfilled through a static quenching mechanism. The simulation of the complexes with the CT-DNA fragment and BSA was studied by using molecular docking software. It further validates that the complexes interact with DNA through intercalative binding mode and that they have a strong interaction with BSA.
