Nature Communications (Nov 2022)

The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians

  • Young Jin Kim,
  • Sanghoon Moon,
  • Mi Yeong Hwang,
  • Sohee Han,
  • Hye-Mi Jang,
  • Jinhwa Kong,
  • Dong Mun Shin,
  • Kyungheon Yoon,
  • Sung Min Kim,
  • Jong-Eun Lee,
  • Anubha Mahajan,
  • Hyun-Young Park,
  • Mark I. McCarthy,
  • Yoon Shin Cho,
  • Bong-Jo Kim

DOI
https://doi.org/10.1038/s41467-022-34163-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Metabolic traits are heritable intermediate phenotypes widely used in assessing the risk of various diseases. By conducting a genome-wide meta-analysis for metabolic traits in 288,137 East Asians, the authors highlight the interplay of common and rare variants on inherited risk of metabolic traits.