Tumour necrosis factor-alpha level among travellers contracted with dengue virus in Bali

Abstract

Dengue infection burden has been predicted increase three times greater recently. Severe dengue infection associated with the high generation of inflammatory cytokines leads to vascular endothelial instability. Hence, the current study aim to evaluate the level of TNF-α among travellers infected with DENV in Bali. An observational prospective study has been conducted on travellers presenting with dengue symptoms who admitted at Kasih Ibu Hospital Bali in 2017. Majority of the sample was female (61%) which median (range) age was 29 (15.4-73.1) years old. The median (range) nadir platelet was 74(29-194) 103cell/μL. The temporal predominant serotype was DENV-3 (29.3%), followed by DENV-2 (24.4%), DENV-1 (13.6%), and DENV-4 (2.4%). The study found concurrent DENV infection. Diagnosis of DF was almost equal with DHF. Level of TNF-α found 3 times higher in DHF than DF patients.