Nature Communications (Aug 2017)
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
- Sameer Agnihotri,
- Suganth Suppiah,
- Peter D. Tonge,
- Shahrzad Jalali,
- Arnavaz Danesh,
- Jeffery P. Bruce,
- Yasin Mamatjan,
- George Klironomos,
- Lior Gonen,
- Karolyn Au,
- Sheila Mansouri,
- Sharin Karimi,
- Felix Sahm,
- Andreas von Deimling,
- Michael D. Taylor,
- Normand J. Laperriere,
- Trevor J. Pugh,
- Kenneth D. Aldape,
- Gelareh Zadeh
Affiliations
- Sameer Agnihotri
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Suganth Suppiah
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Peter D. Tonge
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Shahrzad Jalali
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Arnavaz Danesh
- Princess Margaret Cancer Centre
- Jeffery P. Bruce
- Princess Margaret Cancer Centre
- Yasin Mamatjan
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- George Klironomos
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Lior Gonen
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Karolyn Au
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Sheila Mansouri
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Sharin Karimi
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Felix Sahm
- Department of Neuropathology, Institute of PathologyUniversity Hospital Heidelberg
- Andreas von Deimling
- Department of Neuropathology, Institute of PathologyUniversity Hospital Heidelberg
- Michael D. Taylor
- Department of Surgery, Division of Neurosurgery, University of Toronto
- Normand J. Laperriere
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Trevor J. Pugh
- Princess Margaret Cancer Centre
- Kenneth D. Aldape
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- Gelareh Zadeh
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network
- DOI
- https://doi.org/10.1038/s41467-017-00174-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 7
Abstract
Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.
