Frontiers in Cellular and Infection Microbiology (Aug 2022)
Pleural thickening induced by Glaesserella parasuis infection was linked to increased collagen and elastin
- Huimin Gong,
- Huimin Gong,
- Huimin Gong,
- Liying Chen,
- Liying Chen,
- Liying Chen,
- Yanling He,
- Yanling He,
- Yanling He,
- Kexin Hua,
- Kexin Hua,
- Kexin Hua,
- Bin Ma,
- Bin Ma,
- Bin Ma,
- Yuan Gao,
- Yuan Gao,
- Yuan Gao,
- Xiaojuan Xu,
- Xiaojuan Xu,
- Xueying Hu,
- Hui Jin,
- Hui Jin,
- Hui Jin
Affiliations
- Huimin Gong
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Huimin Gong
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Huimin Gong
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- Liying Chen
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Liying Chen
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Liying Chen
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- Yanling He
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Yanling He
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Yanling He
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- Kexin Hua
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Kexin Hua
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Kexin Hua
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- Bin Ma
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Bin Ma
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Bin Ma
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- Yuan Gao
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Yuan Gao
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Yuan Gao
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- Xiaojuan Xu
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Xiaojuan Xu
- Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
- Xueying Hu
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Hui Jin
- State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
- Hui Jin
- College of Animal Medicine, Huazhong Agricultural University, Wuhan, China
- Hui Jin
- Hubei Provincial Key Laboratory of Preventive Veterinary Medicine, Huazhong Agricultural University, Wuhan, China
- DOI
- https://doi.org/10.3389/fcimb.2022.952377
- Journal volume & issue
-
Vol. 12
Abstract
Glaesserella parasuis is well-known for causing Glässer’s disease, which costs the worldwide swine industry millions of dollars each year. It has been reported the symptom of pleural thickening during Glässer’s disease but this symptom has received little attention. And there is no research on the elements which promote pleural thickening. In this study, pleural thickening was discovered to be associated with increased collagen fibers and elastic fibers. Furthermore, collagen-I and elastin were found to be up-regulated and concentrated in the pleura at the mRNA and protein levels following infection. To summarize, our findings add to the theoretical understanding of Glässer’s disease and provide strong support for further research into the pathogenic mechanism of Glaesserella parasuis and the program’s target treatment.
Keywords
