mSystems
(Aug 2021)
Association between Human Genetic Variants and the Vaginal Bacteriome of Pregnant Women
Wei Fan,
Hui Kan,
Hai-Yan Liu,
Tian-Lei Wang,
Yi-Ning He,
Miao Zhang,
Ya-Xin Li,
Yi-Jie Li,
Wei Meng,
Qing Li,
An-Qun Hu,
Ying-Jie Zheng
Affiliations
Wei Fan
Department of Epidemiology, Fudan University, Shanghai, China
Hui Kan
Department of Epidemiology, Fudan University, Shanghai, China
Hai-Yan Liu
Department of Clinical Laboratory, Anqing Municipal Hospital, Anqing, China
Tian-Lei Wang
Department of Epidemiology, Fudan University, Shanghai, China
Yi-Ning He
Department of Epidemiology, Fudan University, Shanghai, China
Miao Zhang
Department of Epidemiology, Fudan University, Shanghai, China
Ya-Xin Li
Department of Epidemiology, Fudan University, Shanghai, China
Yi-Jie Li
Department of Epidemiology, Fudan University, Shanghai, China
Wei Meng
Department of Epidemiology, Fudan University, Shanghai, China
Qing Li
Department of Obstetrics and Gynecology, Anqing Municipal Hospital, Anqing, China
An-Qun Hu
Department of Clinical Laboratory, Anqing Municipal Hospital, Anqing, China
Ying-Jie Zheng
ORCiD Department of Epidemiology, Fudan University, Shanghai, China
DOI
https://doi.org/10.1128/mSystems.00158-21
Journal volume & issue
Vol. 6,
no. 4
Abstract
Read online
Knowledge about the influence of host genetics on the vaginal bacteriome in pregnancy is still limited. Although a number of environmental and behavioral factors may exert influences on the structure of vaginal bacterial communities, the vaginal bacteriome often undergoes a relatively fixed transition to a more stable and less diverse state as the menstrual cycle stops, which raises questions on the effects of human genetics.
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