Frontiers in Aging Neuroscience (Apr 2021)

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

  • Niels Hansen,
  • Niels Hansen,
  • Aditya Singh,
  • Aditya Singh,
  • Claudia Bartels,
  • Frederic Brosseron,
  • Frederic Brosseron,
  • Katharina Buerger,
  • Katharina Buerger,
  • Arda C. Cetindag,
  • Arda C. Cetindag,
  • Laura Dobisch,
  • Peter Dechent,
  • Birgit B. Ertl-Wagner,
  • Klaus Fliessbach,
  • Klaus Fliessbach,
  • John D. Haynes,
  • Michael T. Heneka,
  • Michael T. Heneka,
  • Daniel Janowitz,
  • Ingo Kilimann,
  • Ingo Kilimann,
  • Christoph Laske,
  • Christoph Laske,
  • Christoph Laske,
  • Coraline D. Metzger,
  • Coraline D. Metzger,
  • Coraline D. Metzger,
  • Matthias H. Munk,
  • Matthias H. Munk,
  • Matthias H. Munk,
  • Oliver Peters,
  • Oliver Peters,
  • Josef Priller,
  • Josef Priller,
  • Nina Roy,
  • Klaus Scheffler,
  • Anja Schneider,
  • Anja Schneider,
  • Annika Spottke,
  • Annika Spottke,
  • Eike J. Spruth,
  • Eike J. Spruth,
  • Stefan Teipel,
  • Stefan Teipel,
  • Maike Tscheuschler,
  • Ruth Vukovich,
  • Jens Wiltfang,
  • Jens Wiltfang,
  • Jens Wiltfang,
  • Emrah Duezel,
  • Emrah Duezel,
  • Frank Jessen,
  • Frank Jessen,
  • Roberto Goya-Maldonado,
  • Roberto Goya-Maldonado

DOI
https://doi.org/10.3389/fnagi.2021.626974
Journal volume & issue
Vol. 13

Abstract

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Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases.Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups.Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode.Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.

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