Pathogenetic aspects of the development of cholelithiasis in patients with metabolic syndrome

Abstract

Nowadays there is a steady tendency to increase the number of patients with gallstone disease and metabolic syndrome. Increasingly, gallstone disease is called a non-canonical cluster of metabolic syndrome, because the main components of metabolic syndrome are also modifiable risk factors for gallstone disease. This article discusses the pathogenetic parallels in the development of gallstone disease and metabolic syndrome - insulin resistance and hormones of adipose tissue, lipid metabolism disorders, immune factors and the cytokine system. There are described possible effects of cholecystectomy on metabolism in patients with metabolic syndrome.

Keywords

• metabolic syndrome
• cholelithiasis
• cholecystectomy
• dyslipidemia
• insulin resistance
• hormones of adipose tissue
• cytokines