Nature Communications (Nov 2022)
Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits
- Lili Liu,
- Atlas Khan,
- Elena Sanchez-Rodriguez,
- Francesca Zanoni,
- Yifu Li,
- Nicholas Steers,
- Olivia Balderes,
- Junying Zhang,
- Priya Krithivasan,
- Robert A. LeDesma,
- Clara Fischman,
- Scott J. Hebbring,
- John B. Harley,
- Halima Moncrieffe,
- Leah C. Kottyan,
- Bahram Namjou-Khales,
- Theresa L. Walunas,
- Rachel Knevel,
- Soumya Raychaudhuri,
- Elizabeth W. Karlson,
- Joshua C. Denny,
- Ian B. Stanaway,
- David Crosslin,
- Thomas Rauen,
- Jürgen Floege,
- Frank Eitner,
- Zina Moldoveanu,
- Colin Reily,
- Barbora Knoppova,
- Stacy Hall,
- Justin T. Sheff,
- Bruce A. Julian,
- Robert J. Wyatt,
- Hitoshi Suzuki,
- Jingyuan Xie,
- Nan Chen,
- Xujie Zhou,
- Hong Zhang,
- Lennart Hammarström,
- Alexander Viktorin,
- Patrik K. E. Magnusson,
- Ning Shang,
- George Hripcsak,
- Chunhua Weng,
- Tatjana Rundek,
- Mitchell S. V. Elkind,
- Elizabeth C. Oelsner,
- R. Graham Barr,
- Iuliana Ionita-Laza,
- Jan Novak,
- Ali G. Gharavi,
- Krzysztof Kiryluk
Affiliations
- Lili Liu
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Atlas Khan
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Elena Sanchez-Rodriguez
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Francesca Zanoni
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Yifu Li
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Nicholas Steers
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Olivia Balderes
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Junying Zhang
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Priya Krithivasan
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Robert A. LeDesma
- Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University
- Clara Fischman
- Department of Medicine, University of Pennsylvania
- Scott J. Hebbring
- Center for Human Genetics, Marshfield Clinic Research Institute
- John B. Harley
- Center of Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital
- Halima Moncrieffe
- Center of Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital
- Leah C. Kottyan
- Center of Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital
- Bahram Namjou-Khales
- Center of Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital
- Theresa L. Walunas
- Department of Medicine, Northwestern University Feinberg School of Medicine
- Rachel Knevel
- Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School
- Soumya Raychaudhuri
- Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School
- Elizabeth W. Karlson
- Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School
- Joshua C. Denny
- Department of Medicine, Vanderbilt University School of Medicine
- Ian B. Stanaway
- Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington
- David Crosslin
- Department of Biomedical Informatics and Medical Education, School of Medicine, University of Washington
- Thomas Rauen
- Department of Nephrology, RWTH University of Aachen
- Jürgen Floege
- Department of Nephrology, RWTH University of Aachen
- Frank Eitner
- Department of Nephrology, RWTH University of Aachen
- Zina Moldoveanu
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Colin Reily
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Barbora Knoppova
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Stacy Hall
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Justin T. Sheff
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Bruce A. Julian
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Robert J. Wyatt
- Division of Pediatric Nephrology, University of Tennessee Health Sciences Center
- Hitoshi Suzuki
- Department of Nephrology, Juntendo University Faculty of Medicine
- Jingyuan Xie
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Nan Chen
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Xujie Zhou
- Renal Division, Peking University First Hospital, Peking University Institute of Nephrology
- Hong Zhang
- Renal Division, Peking University First Hospital, Peking University Institute of Nephrology
- Lennart Hammarström
- Department of Biosciences and Nutrition, Karolinska Institutet
- Alexander Viktorin
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Patrik K. E. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Ning Shang
- Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University
- George Hripcsak
- Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University
- Chunhua Weng
- Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University
- Tatjana Rundek
- Department of Neurology, University of Miami
- Mitchell S. V. Elkind
- Department of Neurology, Vagelos College of Physicians & Surgeons, Columbia University
- Elizabeth C. Oelsner
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- R. Graham Barr
- Division of General Medicine, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Iuliana Ionita-Laza
- Department of Biostatistics, Mailman School of Public Health, Columbia University
- Jan Novak
- Department of Microbiology and Medicine, University of Alabama at Birmingham
- Ali G. Gharavi
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Krzysztof Kiryluk
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- DOI
- https://doi.org/10.1038/s41467-022-34456-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Immunoglobulin A protects against infectious disease and contributes to autoimmune and inflammatory disorders. Here, the authors perform a genome-wide association study for serum IgA levels, identifying 20 genome-wide significant loci, providing new insights into the genetic regulation of IgA levels.
